Chemoreactomic analysis of thiamine disulfide, thiamine hydrochloride, and benfotiamine molecules

A Toxicity Study of Thiamine Hydrochloride.

Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives

BACKGROUND Lipid-soluble thiamine precursors have a much higher bioavailability than genuine thiamine and therefore are more suitable for therapeutic purposes. Benfotiamine (S-benzoylthiamine O-monophosphate), an amphiphilic S-acyl thiamine derivative, prevents the progression of diabetic complications, probably by increasing tissue levels of thiamine diphosphate and so enhancing transketolase ...

Inhibition of Thiamine Pyrophosphate Utilization by Thiamine

The growth of a thiamine pyrophosphate auxotroph of Escherichi coli was inhibited by either thiamine or thiamine monophosphate, and the growth of a thiamine monophosphate auxotroph was inhibited by thiamine. The thiamine pyrophosphate-dependent oxidation of pyruvate was inhibited by thiamine with whole cells of the thiamine pyrophosphate auxotroph but not with cell extracts prepared from the sa...

Observations on the mechanism of thiamine hydrochloride absorption in man.

1. The intestinal absorption of [35S]thiamine hydrochloride was investigated in healthy subjects, malnourished alcoholics and a patient with resection of the jejunum and ileum. Serum and urinary radioactivity was studied after administration of 10 pCi of [35S]thiamine hydrochloride in 1-50 mg of non-radioactive thiamine hydrochloride. 2. Results suggest that intestinal absorption of thiamine hy...

Affinity of Thiamine Propyl Disulfide-s35 to Blood.

The fact that the tissue affinity of thiamine propyl disulfide (TPD) is superior to that of thiamin hydrochloride has been shown by many studies in this country as well as in foreign countries. Especially, the distribution of thiamine in the blood after administration of TPD is worthy of note, i.e., the thiamine concentra tion in the blood, particularly in blood cells, is markedly higher after ...